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KMID : 0370219890330010020
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Yakhak Hoeji
1989 Volume.33 No. 1 p.20 ~ p.29
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The Effect of Eicosapentaenoic Acid on the Immune Response in Mice(Ⅰ)
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安榮根/Ahn, Young Keun
金正勳/李相根/金杏順/Kim, Joung Hoon/Lee, Sang Keun/Kim, Haeng Soon
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Abstract
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The humoral immune response of Eicosapentanoic acid(EPA) was investigated in mice.
ICR male mice were divided into 8 groups and received intraperitoneal injection of EPA(5 mg, 10 mg, 20 mg/kg) for 4 weeks. Cyclophosphamide(5 mg/kg) was administered i.p. 2 days prior to secondary immunization. Humoral immune response was evaluated by antibody titer, hypersensitivity to SRBC (Arthus), plaque forming cell(PFC) and organ weight.
The ontanined results were as followings : The increased rate of body weight, the ratio of liver weight, spleen weight to body weight were decreased by all EPA administration groups as compared to normal group. HA titer, HY titer and Arthus reaction were enhanced according to the increase of EPA doses as compared to normal group. PFC was significantly enhanced by EPA 10 mg administration group. These results suggest that EPA enhances humoral immune response to SRBC in mice, indicating that EPA may block a immunoglobulin synthesis inhibition of arachidonic acid.
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